Abstract - The research was conducted to evaluate the effects of two anaesthetic combinations (Xylazine-Ketamine and Xylazine-Propofol) on clinical and hemato-biochemical profile in dogs. A total of 12 dogs, apparently healthy, age 2-3 years and weighing 12-17 kg were used and randomly grouped into two; X-K (Xylazine @1.1mg/kg IM-Ketamine @10mg/kg IM) and X-P (Xylazine @1.1mg/kg IM-Propofol 2mg/kg IV). Animals were permitted for the anaesthetic procedure after 2-3 days of acclimatization. Clinical parameters such as body temperature (?C), pulse rate (beats/min), respiratory rate (breaths/min.), oxygen saturation (SpO2, %), hematological profile; hemoglobin (Hb, %), total erythrocyte count (TEC, ?106/mm3), total leucocyte count (TLC, ?103mm3), packed cell volume (PCV, %) and, serum biochemical profile; aspartate aminotransferase (AST, IU/L), alanine aminotransferase (ALT, IU/L), bilirubin (mg/dL), creatinine (mg/dL), blood urea nitrogen (BUN, mg/dL), triglyceride (TG, mg/dL) and cholesterol (mg/dL) were recorded and evaluated before 0 minute and after 10, 20, 30, 40 minutes after anesthesia in individual animal. Rectal temperature, Respiratory rate and SpO2 decreased initially at 10 min after induction. It then increased towards the pre-anaesthetics level in both groups. Pulse rate increased initially, and this was decreased gradually towards baseline in both groups. In both groups, haematological values altered after induction with both the combinations and returned to near the baseline when the animal recovered utterly (12 hrs post-induction). Serum biochemical analysis showed that ALT, AST, bilirubin, creatinine, BUN, TG and cholesterol level seriously altered initially after 10 min of induction. In some instances (ALT, AST and TG) the changes continued up to the wake up of animals. They then gradually returned to the initial value. Results of the study reveal that the anaesthetics combination of Xylazine-Ketamine and Xylazine-Propofol exert some systemic effect in body compromising vital organs at a certain level.