Abstract - The present investigation was carried out on rabbits to find out the comparative effects of border plant (Red Bush) and curcumin on morphological changes in wound healing. General anaesthesia was done before creating experimental wounds of 20 mm length and 5 mm depth on either side of the paralumber region. Rabbits were randomly divided into three groups consisting of four animals in each. Fresh curcumin powder was applied in one group, while fresh Red Bush paste was applied in another group. In the third group, methyl extract of Red Bush was applied. All treatments were applied topically. Clinical features including exudation, redness, dryness, cicatrization, pigmentation etc. were compared with all groups during the period of healing. Morpho- logical features including elevation of suture line from the skin surface, swelling area of wound, contraction length per week and width of the sutured area were recorded to determine the healing progress. A higher swelling area (12.78 ? 0.19 mm) was seen in wounds of the Red Bush paste treated group. Elevation of wound surface area was greater (3.62 ? 0.003 cm) in wounds of the curcumin-treated group and lesser (3.51 ? 0.003 cm) in wounds treated with methyl extract of Red Bush. Methyl extract of Red Bush showed the best results within 8 days for complete healing. Curcumin also had a stimulating effect on wound healing activity but was less effective than border plants. Methyl extract of Red Bush is a better topical therapy for wound management in rabbits compared to curcumin.