Abstract - Hydatidosis, zoonotic disorder, is responsible for chronic sufferings of both human and animals. There is no other better treatment option without surgery and there is also a chance of recurrence of infection after surgery. As the existing drugs are not so effective, searching for new protoscolicidal agents become an urgent need. This study investigates the scolicidal activities of the Zingiber officinale and Allium cepa ethanolic extract on hydatid cysts protoscolices. The samples were collected from the infected livers and lungs of goats and sheep. Eosin stain (0.1%) was used to determine the viability of protoscolices and the result was observed in an optical microscope. Results revealed that Z. officinale extract (50 mg/ml) killed all the observed protoscolices after 120 min of exposure. However, if the concentration increases (100 mg/ml), the killing time becomes shorten gradually. Similar kinds of effects were observed in A. cepa, where more than 90% protoscolices were death at 25 mg/ml concentration at 120 min. The results showed that the protoscolicidal effects were dependent on concentration and time. When the scolicidal effects of these two plant extracts were compared to that of two anthelmintic albendazole and ivermectin, it was found that the ethanolic extracts of Z. officinale and A. cepa showed more scolicidal effects. Hence, these plant extracts can be considered as potent scolicidal agents for the treatment of hydatid cysts infection.